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Decoding the role of DNA sequence on protein-DNA co-condensation
Fig 8
Key insights from simulations of DNA sequence-dependent protein–DNA Co-condensation.
First column Cartoon representations of the four DNA models considered in our study. Second column Probability of each monomer being inside the condensate is plotted as a function of monomer position along the contour for a shorter homogeneous DNA (Nm = 50, 
= 0.8, and 
= 84.5 
), heterogeneous DNA I (
= 0.6 and 
= 84.5 
), heterogeneous DNA II (
= 0.6 and 
= 84.5 
), and partial 
-DNA (
= 0.2 and 
= 84.5 
). Third column Representative kymographs are shown for all the models for the same conditions as in the second column. Fourth column Coarsening kinetics of a single final condensate is shown for five independent realizations of homogeneous DNA (Nm = 500, 
= 0.6, and 
= 126.75 
) and heterogeneous DNA I (
= 0.6 and 
= 126.75 
). Coarsening kinetics of two droplets (larger condensate radius in grey and smaller condensate radius in red) are shown for heterogeneous DNA II (
= 0.6 and 
= 84.5 
), and partial 
-DNA (
= 0.6 and 
= 126.75 
). Panels are arranged as homogeneous DNA, heterogeneous DNA I, heterogeneous DNA II, and Partial 
-DNA from top to bottom.
doi: https://doi.org/10.1371/journal.pcbi.1013829.g008