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Decoding the role of DNA sequence on protein-DNA co-condensation

Fig 6

Local interfacial DNA affinity dictates global capillary forces.

A Capillary force as a function of at fixed =0.6. B Capillary force as a function of at fixed . C (top panel) Snapshots of condensates at concentrations marked as (i), (ii), and (iii) in A. Monomers are shown in yellow to red in ascending order protein binding affinity and the proteins are shown in green. C(bottom panel) Bar plots represent monomer-protein binding affinities. The grey-shaded region shows the interface. The red curve shows the probability of the monomer being inside the condensate. D capillary force correlates with average interfacial affinities. Grey points show the capillary forces and interfacial affinities for 30 individual replicates at the six values in A. The purple points show the mean and standard deviation at each . The red dashed line is a fit to the mean data.

doi: https://doi.org/10.1371/journal.pcbi.1013829.g006