Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics
Fig 6
Distribution of E/I Ratio Differences on the Cortex.
(A) The distribution of the E/I ratio rendered onto the cortical surface. (B) The administration of LSD induces a compression of the global E/I ratio towards the center along the principal functional gradient. (C) The distribution of E/I ratios across the 7 RSNs under LSD and placebo conditions shows that the peak E/I ratio in the primary cortex under LSD is situated to the left of the corresponding peak observed under placebo, whereas the peak in the associative cortex under LSD is located to the right of the placebo peak. (D) Pearson correlation between the E/I ratio difference and the densities of 5-hydroxytryptamine-2A (5-HT2A) receptors and glutamate receptors.