Lysergic acid diethylamide-derived excitatory/inhibitory ratio change enhances global synchrony in functional brain dynamics
Fig 2
Visualization of BOLD signals and Kuramoto order parameter for subject 001 and results of paired t-test.
(A) The Kuramoto order parameter (OP) of Subject 001 under LSD (red solid line) and placebo (black solid line) conditions across 216 time points. The dashed lines represent the mean OP over time for each condition, with a red dashed line indicating the LSD condition and a black dashed line indicating the placebo condition. (B) Boxplots of OP (left panel) and the standard deviation of the OP, STD(OP), (right panel) under LSD and placebo conditions. Each boxplot shows the distribution of data, with the central horizontal line representing the median, the box indicating the interquartile range (IQR) between the first (Q1) and third (Q3) quartiles, and the whiskers extending to the minimum and maximum values within 1.5 times the interquartile range from Q1 and Q3. Statistical details: OP (LSD vs. placebo), p = 0.0101, Cohen’s d = 0.7671; STD(OP) (LSD vs. placebo), p = 0.0140, Cohen’s d = 0.7246.