Using evolutionary context to classify difficult protein folds
Fig 2
Comparison of overlap fractions of well-assigned DPAM domains and corresponding TED CNF domains.
432 domains are consistently defined domains with both DPAM overlap fraction and TED overlap fraction greater than 0.8 (bounded by red dashed lines). 888 domains have DPAM overlap fraction less than 0.6 and TED overlap fraction greater than 0.8 (bounded by magenta dashed lines), suggesting that TED CNF domains are embedded mainly in the ECOD domains. 202 domains have TED overlap fraction less than 0.6 and DPAM overlap fraction greater than 0.8 (bounded by orange dashed lines), suggesting that ECOD domains are primarily embedded in the TED CNF domains. The remaining 968 domains fall into intermediate cases where neither definition is largely embedded in the other, indicating partial overlaps or more complex boundary relationships between TED and DPAM.