PyFibers: An open-source NEURON-Python package to simulate responses of model nerve fibers to electrical stimulation
Fig 7
Effects of modifying fiber ultrastructure on activation thresholds of an MRG fiber, using the code in Box 4. A) Diagram of ultrastructure parameters modified during the analysis. Note that we did not include an analysis of varying number of myelin lamellae, which is also modified by the fiber diameter (D). B) Effects on activation thresholds normalized by the threshold for an unaltered 10 μm MRG fiber. Parameters not described as changed were held constant. For D, all parameters were varied according to the relationships defined by the MRG-interpolation model. For daxon_node, the diameter of the nodes of Ranvier was varied. For INL, the internodal length (i.e., section lengths) was varied. For Dall, all axonal and myelin diameters were varied.