Integrative multi-omics framework for causal gene discovery in Long COVID
Fig 5
Network plot highlighting a network driver gene for Long COVID.
Our analysis identified CREBBP as a key network driver gene for Long COVID, supported by existing literature, with 273 total interactions (153 incoming, 120 outgoing). Connected genes are represented by three shapes based on network control properties: ellipses for critical genes (removal increases the required driver nodes), diamonds for ordinary genes (removal maintains the driver nodes), and round rectangles for redundant genes (removal preserves the control). The three most enriched pathways are shown in green, purple, and blue, with node sizes proportional to their K-degree (network connectivity).