Library size-stabilized metacells construction enhances co-expression network analysis in single-cell data
Fig 2
Preservation of co-expression modules constructed by different methods across major cell types.
Co-expression modules were constructed separately for excitatory neurons (EN), inhibitory neurons (IN), oligodendrocytes (OC), astrocytes (AC), and microglia (MC). The preservation of these modules was subsequently evaluated in a fully independent single-cell sequencing dataset using the Z-Summary statistic. A Z-Summary > 10 indicates strong evidence of preservation, while a Z-Summary > 2 suggests moderate preservation.