Inferring pathway activity from single-cell and spatial transcriptomics data with PaaSc
Fig 3
Evaluation of the performance of PaaSc on 136 annotated scRNA-seq datasets.
(A) A bar plot illustrating the number of datasets containing each of the five cell types analyzed: B cells, CD8 + T cells, macrophages, Tregs, and NK cells. (B) Box plots comparing the performance of PaaSc and 7 competing tools in distinguishing B cells from other cell populations, as measured by AUC scores based on B cell-specific markers. (C) A bar plot showing the number of datasets in which each tool achieved the highest AUC score for B cell identification. (D) Four heatmaps comparing the performance of PaaSc and competing tools in scoring pathway activity for CD8 + T cells, macrophages, Tregs, and NK cells. The datasets were grouped according to which tool achieved the highest accuracy for each cell type. (E) Stacked bar plots summarizing the number of datasets in which each tool achieved the best performance for each cell type.