Optimization of experimental designs for biological rhythm discovery
Fig 5
Irregular designs are robust to perturbations in measurement timing.
(A) Measurement schedules before (top) and after (bottom) jittering. Jittered designs were generated by randomly perturbing the measurement times of equispaced and irregular designs with Gaussian white noise. (B) Worst-case power of jittered designs (y-axis) as a function of noise intensity (x-axis) for various sample sizes (panels). The bars indicate the interquartile range for ensembles (n = 100) jittered designs. Irregular designs were optimized for the frequency window and
using differential evolution with same parameters as Fig 4. Power was calculated assuming an amplitude A = 1.