Individual trajectories for recovery of neocortical activity in disorders of consciousness
Fig 3
Modelling synaptic plasticity in DoC.
Panels A and B show simulated power spectra for individual subjects during excitatory corticothalamic (A) and excitatory cortical synaptic plasticity (B). Panel C shows the Kullback-Leibler (abbreviated to KL) divergence during either cortical plasticity (D) or corticothalamic plasticity (E). Simulated power spectra were assessed for their similarity (low KL value) with those from healthy control subjects, with significant differences denoted by ** for p < 0.001 and* for p < 0.05. Panel D shows the group-averaged power spectra during the course of corticothalamic plasticity for the UWS and MCS groups. The same group-averaged power spectra are illustrated for different etiologies (E). Abbreviations: healthy controls (HC), minimal conscious state (MCS), unresponsive wakefulness syndrome (UWS), excitatory corticothalamic synaptic strengths (GESE), inhibitory corticothalamic synaptic strengths (GESRE), Excitatory cortical synaptic strengths (GEE), inhibitory cortical synaptic strengths (GEI), intrathalamic synaptic strengths (GSRS), synaptic decay and rise constants (α and β), corticothalamic time delay (t0).