Detecting polynucleotide motifs: Pentads, hexads, and beyond
Fig 6
Confirmation of polyad formation using NMR restraints for the dimeric RNA G-quadruplex structure (PDB ID: 2RQJ).
(A) Schematic representation of distance restraints between exchangeable protons and their partners in residues G1 and A3, which form a sheared G:A base pair underlying hexad formation. (B) Selected lines from the 2rqj.mr restraint file that report on the in-plane position of residue A3 and the formation of hydrogen bonds between G1 and A3. For clarity, only restraints involving exchangeable protons are shown. The lines in (B) are shaded in colors that correspond to the interaction paths marked in (A), indicating which restraint supports which structural feature.