Multi-cellular network model predicts alterations in glomerular endothelial structure in diabetic kidney disease
Fig 8
Simulated glucose input concentration profiles for time-dependent glucose control interventions.
For 6–20 weeks, the 100 G(t) trajectories (Fig 3) for the virtual mouse population were used as the inputs before and without intervention, and the means of the 100 profiles are plotted. The “No intervention” case (solid black line) is the glucose inter-subject variability scenario. In silico glucose control “intervention" was applied at 4 weeks (dotted black line) and 10 weeks (dashed gray line) by resetting glucose to its initial value . Glucose concentration data values are from Lee et al. [22] (blue circles) and Finch et al. [10] (red triangles). Data are shown as means ± standard deviations.