Multi-cellular network model predicts alterations in glomerular endothelial structure in diabetic kidney disease
Fig 2
Simulated glucose input concentration profiles.
Simulated glucose input concentration profiles (black dashed curve on left axis) over 20 weeks using the linear fit for 2–6 weeks from Eq (1) and piecewise constant values of glucose at the means of the observed data in diabetic mice for 6–20 weeks. Dimensional glucose values G(t) are shown on the left axis, and normalized values of glucose reaction weight obtained using Eq (2) are shown on the right axis (black dotted curve). Glucose concentration data values are from Lee et al. [22] (blue circles) and Finch et al. [10] red triangles for male ob-/ob- mice. Data are shown as means ± standard deviations.