Multiscale networks in Alzheimer’s disease identify brain hypometabolism as central across biological scales
Fig 4
Network permutation for negative controls.
In this example, in the first permutation, the edges (b,c) and (d,e) were exchanged with the edges (b,d) and (c,e). For the second permutation, the edges (a,e), (b,c) were swapped with the edges (a,c) and (b,e). In the third permutation, the top network’s edge swap was applied first, followed by the middle network’s edge swap: (a,b), (b,c) and (d,e) were exchanged for (a,c), (b,d) and (b,e). Three possibilities were considered when determining if the paths from the original network appeared in the permuted networks. In the first permutation, the path existed in the permuted network and was also identified as a top path. In the second permutation, the original path existed in the permuted network but was not identified as a top path. Finally, in the third permutation, the original path did not exist in the permuted network at all.