Transmission thresholds for the spread of infections in healthcare facilities
Fig 2
Effect of length-of-stay interventions on facility basic reproduction number.
Calculations of the facility reproduction number, , for Model 3 with the following fixed values calibrated to pre-intervention CRE data in long-term acute care hospitals (Table 3): transmission rate
per day, clinical detection rate
per day, colonization clearance rate
per day, and contact precaution effectiveness
. Length of stay was governed by a 4-parameter mixed exponential–gamma distribution, and specific parameters were varied from the baseline values (Table 3) in a direction that decreased the overall mean length of stay from left-to-right in each of the sub-figures, while holding all other parameters constant. Upper-left: both the exponential rate parameter
and the gamma rate parameter
were simultaneously increased by the same factor from their baseline values. Upper-right: the exponential rate parameter
was increased from its baseline value. Lower-left: the gamma rate parameter
was increased from its baseline value. Lower-right: the fraction of patients following the exponential distribution
was decreased from its baseline value.