The mechanism of dynamic steady states in lamellipodia
Fig 7
Different modes of dynamic steady states exist.
(A) Two ways to rescue the case showing a negligible flow with RM = 0.0015, AFA = 0.175, and k-,A = 6 s-1. Since contractile forces were insufficient to overcome the frictional forces in this case, it was able to be rescued by either increasing RM to 0.004 or reducing AFA to 0. (B) Rescuing a case exhibiting a minimal flow with RM = 0.004, AFA = 0.15, and k-,A = 10 s-1. Since actin depolymerization was too fast compared to flow speed, this case was able to be rescued by enhancing flow speed, either by increasing RM to 0.01 or decreasing AFA to 0.05. (C, D) Kymographs of actin density as a function of y position and time for cases shown in (A) and (B), respectively.