Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses
Fig 9
Electric properties of the dendritic terminal segments of the mouse (red, 35 terminals) and human (blue, 37 terminals) neuron morphologies in corresponding computational neuron models.
(A) Electrotonic length of the terminal segments. (B) Shape of EPSP in the soma (dark line) and in the terminal dendritic segment (light lines) at different locations on the terminal dendritic segment (points 1-5). The glutamatergic synapse is located at the tip (point 1). (C-D) Response to simulated glutamatergic synaptic inputs, AMPA and NMDA. (C) Distributed asynchronous synaptic drive. Left: 10 synapses placed uniformly along the terminal segment; right: membrane depolarisation in the dendritic segment (light lines) and soma (dark lines), error bars for STD, variability for all terminals. (D) Clustered synchronous synaptic drive. Left: synapses are placed in the middle of a terminal segment and stimulated in sequence with 1 ms interval; right: EPSPs in the dendritic segment (light lines) and soma (dark lines). Prolonged NMDA-spike in a dendrite may trigger action potential in the soma (truncated). Inset, shows the effect of setting the NMDA part to 0. Scale bars in (B-D) are 100 μm.