Mouse and human striatal projection neurons compared - somatodendritic arbor, spines and in silico analyses
Fig 8
Simulation of the detailed biophysical models of SPNs for mouse (red) and human (blue).
(A) Experimental current clamp recording from the mouse D1-positive SPNs. (B-C) Simulated neuron models optimised to the experimental data (A) using mouse (B) and human (C) morphologies. (D-E) Ensembles of validated models optimised to three selected SPNs, experimental data plotted in grey. Subthreshold current-voltage responses (D) and suprathreshold discharge rates (E) are shown. Shaded areas display the range of the values within each ensemble. (F) Magnified current-frequency relation for one set of models (from the middle of (E)). Black color for experimental data, red for the mouse and blue for the human morphologies. (G) Current-frequency relation with exchanged morphologies, mouse SPN reconstruction is scaled to human proportions (retains red color) and human reconstruction is downscaled to mouse dimensions (retains blue color). Rescaled mouse and human SPN reconstructions behave as valid replacements of each other in electrophysiological simulation.