A comparative computational analysis of IFN-alpha pharmacokinetics and its induced cellular response in mice and humans
Fig 5
Development and validation of the mouse PBPK model to the venous blood plasma concentration.
Model fits of the PBPK model to experimental data for IFN-α concentration in blood plasma after i.v. injection of a single dose of 4.43 µg or 3.5 µg IFN- α from Bohoslawec et al. (upper left, [17]) or Rosztoczy et al. (upper right, [19]), respectively, and model validation against Kiuchi et al. (lower left, mix of IFN- α/IFN-β and a data set produced for this study (lower right) after i.v. injection of a single dose of 3.33 µg or 0.0357 µg IFN- α respectively.