Evaluating place cell detection methods in Rats and Humans: Implications for cross-species spatial coding
Fig 2
Place Cell Identification Methods in Rats.
a) Task Schematic. Rats traverse bi-direnctionally along a 250 cm linear track to obtain water rewards located at each end (Directions A and B). b) Proportion of neurons identified as significant by ANOVA permutation testing across brain regions. CA1 and CA3: Hippocampus, DG: Dentate Gyrus, EC: Entorhinal Cortex. c) Proportion of neurons exceeding the SI threshold of 0.25 (light red) and those confirmed by SI permutation testing (dark red) across brain regions. d) Proportion of neurons classified as significant as a function of increasing ANOVA F-statistics. e) Same as in d), plotted against Spatial Information Scores. f) Agreement between permutation-based SI classification and ANOVA classification as a function of increasing F-statistics. g) Same as f., plotted against spatial information scores. Dashed lines in d. and f. mark the observed threshold for ANOVA (F = 2.0); dashed lines in e. and g. indicate spatial information threshold (SI = 0.25). h) Top: Comparison between SI permutation testing (p < 0.05) and ANOVA permutation testing (p < 0.05). Bottom: Comparison between SI thresholding (SI > 0.25) and ANOVA classification. Percentages indicate the proportion of neurons in each classification category.