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Effects of tDCS of the DLPFC on brain networks: A hybrid brain modeling study

Fig 3

The stimulation effects of two DLPFC-tDCS protocols on brain functional network.

(A) Changes in functional connectivity (FC) following DLPFC-tDCS compared to Without-tDCS. These results were visualized using the GRETNA toolbox [32]. (B) Global topology properties changes for Without-tDCS, left DLPFC-tDCS, and right DLPFC-tDCS. Statistical comparisons were conducted between the two DLPFC-tDCS protocols and Without-tDCS using a paired sample t-test. Data are expressed as Mean ± SD. *: , **: , ***: . (C) Changes in FC within and between resting-state networks (RSNs) of two DLPFC-tDCS protocols. Whole-brain FC and FC within and between RSNs were statistically compared between two DLPFC-tDCS protocols and a Without-tDCS condition using a paired sample t-test (). Only nodes with significant differences (paired sample t-test) are colored, while the remaining are white. The color bar indicates the statistical t-value. (D) Between whole-brain and anodically stimulated region FC. Brain regions were categorized into “High-SC” (top 10 regions with the stronger SC to anodically stimulated region) and “Low-SC” (remaining 57 regions). Data represent the t-value for significant changes in FC between whole brain and anodically stimulated regions under two DLPFC-tDCS protocols compared to the Without-tDCS condition. These results were visualized with the BrainNet Viewer toolbox [31].

doi: https://doi.org/10.1371/journal.pcbi.1013486.g003