A multi-frequency whole-brain neural mass model with homeostatic feedback inhibition
Fig 4
Modulation of oscillatory frequency in whole-brain simulations.
Normalized power spectral density (PSD) as a function of: A) global coupling, K, in the whole-brain model, with a fixed target of ρ = 2.5 Hz. B) target (desired) firing rate in the whole-brain model, with a fixed K = 0.5. C) inhibitory synaptic plasticity (ISP) time constant, τ. The values shown here are the average of 50 random seeds. D) Example of EEG traces for a fixed K = 0.5, rα = 0.5, τ = 2 sec, and different values of ρ. E) Relationship between the nodal strength, from the structural connectivity matrix, and the time-averaged feedback inhibition (mean C4), for different values of global coupling K. F) Slopes of the linear regressions in (E), as a function of global coupling. 10 random seeds were used for these simulations. G) Convergence time vs ISP timescale. The convergence time (in seconds) was defined as the first time the ROI-averaged C4 reached 63.2% of its total change from the initial to the final steady state in a noise-free simulation.