Reconstructing noisy gene regulation dynamics using extrinsic-noise-driven neural stochastic differential equations
Fig 3
Simplified schematic of the NFB Signaling Network.
TNF binds its receptor, activating IKK, which degrades IBα and releases NF
B. The free NF
B translocates to the nucleus and promotes I
Bα transcription. Newly synthesized I
Bα then binds NF
B and exports it back to the cytoplasm. Red arrows indicate noise that we consider in the corresponding SDE system.