Topology across scales on heterogeneous cell data
Fig 5
PWDS of red and white pulp cell populations in the murine spleen tissue.
Visualisation of PWDS for the red and white pulp in a healthy sample (BALBc-1) and a diseased sample (MRL-4). Triangles correspond to loops detected by PH with alpha complexes. Red triangles correspond to loops formed by proximal cells, blue ones to loops formed by distal cells, and the intensity of colour is set according to the prominence of the feature. The parameters of the colour gradation depend on the cell type as in the example in the Methods section: and
. PH detects the coarse structure of the spleen, i.e. the noisy holes left in the red pulp by the white pulp as prominent loops (intense-red triangles). The presence of more numerous small light-blue triangles in the red pulp PWDS of diseased samples indicates a higher level of infiltration of the red pulp cells inside the holes left by the white pulp.