Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: In silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain
Fig 10
Best models of the 764-2191 region of WT-VWF and R1205H-VWF models bound to the N-terminal (1-266) domain of platelet GpIbα.
For comparison, the crystal structure of the N-terminal (1-266) region of GpIbα bound to the VWF A1 domain (pdb: 1SQ0) is also shown. The side chain of interacting residues of GpIbα is shown in warm pink, whereas those of VWF are shown as blue sticks. The models were generated by the HADDOCK program, whereas the rendering was accomplished with Pymol.