Natural variants of von Willebrand factor R1205 causing von Willebrand disease with accelerated von Willebrand factor clearance: In silico docking models and energetics of the interaction with both LRP1 and GpIb A1 domain
Fig 2
Superposition of WT-VWF (green ribbon) and p.R1205H (cyan ribbon).
The region R1392-R1399 and R1943, involved in binding to LRP1 domain IV, are shown as yellow sticks and red sticks for WT and p.R1205H VWF, respectively. The R1943 side chains of both WT (yellow sticks) and p.R1205H variant (red sticks) are also shown. Note the large topological change for the region S764-T789, likely deriving from a huge conformational flexibility (curve red arrow). The superposition and alignment of the two structures were performed using the PyMOL program.