An efficient and flexible framework for inferring global sensitivity of agent-based model parameters
Fig 2
SMoRe GloS recapitulates global sensitivity of cell culture ABM.
A) ABM storyboard showing cells by location and cell-cycle phase. B) Time series of the G1/S and G2/M cell-cycle phases. C) ABM parameters included in the sensitivity analysis. The yellow box highlights local spatial parameters that are not explicitly captured by the surrogate model (SM). D) RSS distribution of SM fits to all ABM parameter vectors. Orange line indicates the log-normal distribution that best fits this distribution. E) Identifiability donuts of SM parameters where color indicates the identifiability index, and area the proportion of ABM parameter vectors for which the given SM parameter had that index. F) MOAT sensitivity analysis results using the ABM (Direct, black bars) and SMoRe GloS (Indirect, blue bars), ranked by decreasing sensitivity using the direct method. Spatial parameters not explicitly captured by the SM are highlighted in yellow.