CytoSpatio: Learning cell type spatial relationships using multirange, multitype point process models
Fig 6
A, B) Interaction graphs similar to Fig 5A are shown for all five ranges (A) and for just the first range (B). C) Heatmap showing the pairwise spatial interaction scores between endothelial cells, fibroblasts, and other cell types. Each cell displays the 90% trimmed mean interaction score (top) and the Winsorized standard error (bottom) within the first distance range across 59 images. Among all combinations, the fibroblast–endothelial cell pair exhibits the strongest positive spatial association, with relatively low variability across samples. D) Similar heatmap for self-interactions for all cell types. Fibroblasts and myeloid cells exhibit the strongest self-interaction. E) Scatter plot comparing interaction scores between myeloid cells and PD-1 negative or positive T cells for 59 images. F) Scatter plot of interaction scores between migratory dendritic cells (migDCs) and PD-1 negative or positive T cells. Only images with scores the range (–2, 2) on both axes are shown to highlight the overall trend.