Mutations in tumor signaling, metastases, and synthetic lethality establish distinct patterns
Fig 5
Breast cancer specific subnetwork.
(A) Bubble plot representing the number and fraction of pathway-mutation pair- tumors in each tissue by node size and color, respectively. On the x-axis and y-axis there are 10 tissues and 25 pathways, respectively. Bowel and uterus have mutation pairs across all listed pathways while in breast, lung and pancreas tissues they accumulate in specific pathways including PI3K/AKT, MAPK, FoxO, Neurotrophin, mTOR. (B) Breast cancer specific subnetwork shows seed proteins, oncogenes and tumor suppressors obtained with the Page Rank algorithm from Omni Path with the seed proteins that have mutation pairs, and the tissue specific fraction is greater than 0.5. Blue nodes are the proteins from the PPI network, pink nodes are the seed proteins which are mutation pair components. Transcription factors (TFs) are V-shaped nodes. The border color is green if the gene is tumor suppressor gene and red if oncogene. The edges are solid lines if there is an edge between nodes in the PPI network that contribute to a mutation pair. Dashed lines depict the direct interaction in the PPI. Source and target shape are derived from TRRUST representing the activation or repression. TFs RB1 (encodes the protein Rb1), APC (encodes the protein APC), CTNNB1 (encodes Catenin Beta-1), MYC (encodes the protein Myc), TP53 (encodes the protein p53).