Multi-context modeling of driver pathways reveals common and specific mechanisms across 23 cancer types
Fig 5
Three environmental agents promote tumor progression. Specific signaling pathways in patients with risk exposures to tobacco (A), alcohol (B) and high BMI (C) are illustrated on the left side, while the control groups without harmful habits or abnormal indices are shown on the right.
The pie chart in the middle shows the proportions of the two groups. The heatmaps on both sides exhibit the gene mutation profiles of specific genes in the exposure group (the two maps on the left) and the control group (the two maps on the right) when parameter K is 5. Heatmaps in the same horizontal line share the same gene set. Genes enriched in identified pathways in the middle are filled in dark blue.