Multi-context modeling of driver pathways reveals common and specific mechanisms across 23 cancer types
Fig 4
Interpretation of signaling pathways in pediatric and adult tumors.
(A) Common and specific pathways of acute myeloid leukemia and glioblastoma in adults and children. (B, D) Specific signals of two hematopoietic tumors (B) and four neural tumors (D). The pathways labeled on directed edges represent significant signals specific to one cancer at the tail compared to another at the arrowhead. (C, E) Corresponding to (B) and (D), genes enriched in identified pathways are stacked from bottom to top and marked in dark blue. The remaining genes, depicted in light blue, are also identified by ModSDP but are not explicitly annotated for enrichment in the corresponding signaling pathway. Both dark blue and light blue genes are displayed under the same parameter K. Cytokine signaling*: Cytokine signaling in immune system; Embryonic*: Embryonic and induced pluripotent stem cells and lineage-specific markers; CFTR activity*: Regulation of CFTR activity.