Cardiogenic and chronobiological mechanisms in seizure-induced sinus arrhythmias
Fig 6
Dissecting key mechanisms governing circadian and vigilance state regulation of seizure-induced SANC firing patterns.
Representative oscillatory (labeled as 5 in Fig 5B–E) seizure events under different circadian (at ZT18 (A), ZT12 (B), and ZT6 (C)) and vigilance state (forced sleep at ZT18 (A-i) and forced awake at ZT6 (C-iii)) conditions. Time-of-day changes in PNA (A-iii-a; ZT18) (C-i-a; ZT6), CRBT (A-iii-b; ZT18) (C-i-b; ZT6), and LCR (A-iii-c; ZT18) (C-i-c; ZT6) were applied individually to dissect the relative contributions of each circadian factor in shaping distinct SANC firing patterns at ZT18 (upper green box) and ZT6 (lower green box), respectively.