Therapeutic targeting of oligodendrocytes in an agent-based model of multiple sclerosis
Fig 5
The averaged results across 40 simulations with and
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These results represent the expected disease course of an untreated patient. The extremes across the 40 simulations are indicated by the shading around each averaged result. The three relapse events, each 4 weeks in duration, are indicated by the grey shading. a. The average population of primed T cells (yellow), perivascular macrophages (purple) and reactivated T cells (blue). b. The proportion of the myelin population that is fully intact (light green), partially damaged (green) and fully damaged (dark green). c. The proportion of oligodendrocytes that are myelinating (pink), nonmyelinating (dark pink), and have undergone apoptosis (purple).