EUP: Enhanced cross-species prediction of ubiquitination sites via a conditional variational autoencoder network based on ESM2
Fig 5
Integrated Gradients (IG) analysis for ubiquitination site predictions in Homo sapiens, encompassing.
(a) Feature dependence plots for the top four most important features (K_feature_1542, K_feature_696, K_feature_461, and K_feature_2502), illustrating the relationship between feature values and feature attribution (IG) values..(b) A dense plot displaying the density distribution of the top four features’ values, highlighting variations in feature value distributions across K_feature_1542, K_feature_696, K_feature_461, and K_feature_2502.(c) A swarm plot of log-transformed IG values for the top four features, accompanied by Mann-Whitney U tests for statistical significance. The median log-transformed IG values and p-values indicate distinct patterns in feature importance, with K_feature_1542 showing the highest impact.