Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity
Fig 8
Effects of input strength disparity and engram overlap on retrieval.
(A) to (D) Input strength disparity task: (A) Cue schematic: two CA3 engrams are cued with different input strengths. (B) Example of the learned Rc weight matrix. (C) CA3 engram firing rates during retrieval; two example trials with the same cue are shown: (C1) memory A is retrieved, (C2) memory B is retrieved. (D) Retrieval performance versus input strength disparity, comparing with (blue) and without (red) selective inhibition. Performance is measured as the mean retrieval success rate over 15 bias samples 50 repeats each. (E) to (H) Overlap task: (E) Cue schematic: two overlapping engrams are cued equally. (F) Example learned Rc weight matrix. (G) CA3 engram firing rates for example trials with the same cue: (G1) memory A is retrieved, (G2) memory B is retrieved. (H) Retrieval performance versus percentage overlap between engrams, comparing with (blue) and without (red) selective inhibition.