Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity
Fig 4
DG activity and pattern separation.
(A) Spike raster during encoding of 10 distinct inputs (A to J). Plotted are neurons in the superficial EC, and excitatory and inhibitory neurons in both DG layers (hilus and GCL). 50 of the 100 hilus excitatory neurons and 50 of the 400 GCL inhibitory neurons are shown for visualization. The 16 excitatory GCL neurons encoding the 10 inputs (out of 800) are highlighted. (B) Pattern separation performance of the DG. (C) Histogram of engram overlaps: the similarity of DG output (GCL excitatory) engrams versus similarity of superficial EC input patterns. Most outputs fall into low-overlap bins, indicating robust separation.