Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity
Fig 2
Illustrations of CA3 engram formation inducing selective inhibition.
(A) The engram formation in CA3 driven by DG induces selective inhibition. Inhibitory neurons activated by mossy fibers inhibit most of the excitatory neurons. The surviving excitatory neurons and the activated inhibitory neurons form a neural assembly through STDP. (B) Distribution of CA3 neurons based on the number of stored memories. (C) Characterization of CA3 connections with inhibitory neurons for global versus selective inhibition. In the case of global inhibition, inhibitory neurons suppress excitatory neurons without regard to which engram they represent. In contrast, for selective inhibition, inhibitory neurons associated with a specific engram do not inhibit excitatory neurons within that same engram. (D) The inhibitory influence of one engram on others as a function of the degree of overlap between engrams.