Impact of ligand binding on VEGFR1, VEGFR2, and NRP1 localization in human endothelial cells
Fig 9
Differences in VEGFR1, VEGFR2 and NRP1 trafficking in the absence of ligands (steady state) and presence of ligands in HUVECs.
A, VEGFR1, VEGFR2, NRP1 are constitutively trafficked in the absence of ligands in HUVECs. B, VEGFR2 internalization is faster as a result of VEGF165a treatment. PLGF treatment has no impact on VEGFR1, VEGFR2 or NRP1 trafficking in HUVECs. The size of the arrow represents the amount of receptor movement. The size of the receptor represents the expression level relative to other receptors shown here.