Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion
Fig 8
The spatiotemporal distribution of radiopharmaceuticals that internalized into tumor cells at (A) 500 min, (B) 1000 min, (C) 3000 min, (D) 6000 min, and (E) 30000 min post-treatment for patient 1.
(F) Different absorbed doses (due to the contribution of peptides internalized into cells) calculated by PBPK vs. CDR models.