Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion
Fig 5
Validation of PBPK model and parameter estimation.
By employing post-treatment data obtained from γ-camera images for four patients [42], the designed PBPK model is fitted to the acquired data, facilitating the customization of RPT for personalized treatment strategies. Details of the fitting procedures—including optimization techniques and convergence criteria—as well as the statistical outcomes of the parameter estimation are provided in Figs A-D and Tables C-F in S2 Text.