Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion
Fig 4
Interstitial fluid pressure (IFP) and intravascular fluid pressure (IVP) validation; (A) Simulated distribution of IFP and (B) IVP within the tumor microenvironment.
These simulations illustrate the elevated internal pressures characteristic of solid tumors. Notably, when an inlet pressure of 25 mmHg is applied, the corresponding microvascular pressure reaches 19.8 mmHg, while the interstitial fluid pressure rises to 14.8 mmHg, indicating a significant internal buildup of pressure within the tumor tissue. (C) An analysis correlating intravascular and interstitial pressure across various tumors in realistic models suggests that both pressures are elevated with a minimal disparity between them [122]. This trend is attributed to structural abnormalities in the tumor vasculature, dysfunctional lymphatic drainage, and the dense packing of tumor cells. Elevated IFP impedes convective transvascular transport and can hinder the delivery and retention of therapeutic agents by promoting outward fluid convection, potentially facilitating drug efflux from the tumor. While this study does not account for lymphatic drainage, monitoring IFP and IFV remains vital for understanding drug delivery dynamics and improving therapeutic strategies in solid tumors.