Multi-scale computational modeling towards efficacy in radiopharmaceutical therapies while minimizing side effects: Modeling of amino acid infusion
Fig 3
The modeling of angiogenesis process over a span of 30 days is depicted and compared qualitatively with actual microvasculature surrounding and within tumors.
The models demonstrate that newly formed blood vessels near and within the tumor exhibit significant branching and looping, consistent with in vivo observations. Comparing angiogenesis models that correspond with in vivo studies highlights that newly formed blood vessels near and within the tumor exhibit significant branching and looping [67]. The timeline includes snapshots at specific intervals: (A) Day 5, (B) Day 25, and (C) Day 30, showing the progression of vascular development in the model. Additionally, (D) represents tumor vasculature captured through optical frequency domain imaging [119], serving as a reference for comparison.