Evolutionary divergence of induced versus constitutive antiviral gene expression levels between primates and rodents
Fig 6
Evolutionary characteristics of genes that transcriptionally diverge between human-mouse in dsRNA response.
Distributions of (A) percentage of sequence identity between human and mouse orthologs, (B) ratio of non-synonymous to synonymous substitutions (dN/dS), (C) gene evolutionary age (higher values denotes older age), and (D) rate of gene gain and loss across vertebrates (p-values for each gene’s rate are shown), for (from left to right): the set of DE genes (in grey) that includes all genes significantly upregulated in either human and/or mouse in response to dsRNA stimulation (FDR-corrected P-value<0.01 and FC > 0), human constitutive-low, mouse constitutive-low, mouse-constitutive-high, human-constitutive high. Group colors, sizes and genes are as in Fig 4. FDR-corrected P-values are shown, one-sided Mann–Whitney tests were performed for each of the 4 groups against all DE genes. For comparison, the values of the group of all 1-to-1 orthologs are also shown.