Proteostasis signatures in human diseases
Fig 7
Central role of mid-stage regulatory proteins in the proteostasis network perturbations in AD. The functional interaction network of AD-associated proteostasis network genes (from all disease stages) are shown.
Genes affected in the early stage are depicted as blue nodes; mid stage as beige nodes; and late stage as red nodes. A stage-wise quantification of the degree and betweenness centralities of the AD-associated proteostasis network genes within the network presented reveals that proteostasis proteins perturbed in mid-stage AD (Braak 2/3) are most central in the AD proteostasis network. The degree centrality measures the number of connections of a protein within the network, and the betweenness measures the extent to which a protein lies on the shortest path between protein pairs within the network. Proteins with high degree and betweenness are likely to play key regulatory roles in their functional networks. The upper and lower bounds of the boxplots represent the interquartile range of degree/betweenness for genes associated with each disease stage. The line contained in the box represents the 50th percentile of degree/betweenness for genes associated with each disease stage. Whiskers represent non-outlying extreme points while data points beyond the whiskers are plotted individually.