Proteostasis signatures in human diseases
Fig 6
Temporal patterns of ALP and UPS perturbations in the progression of cancer and neurodegenerative diseases.
The proportion of the ALP and UPS genes affected in each stage of disease is calculated and depicted. While ALP and UPS perturbations are indicative of disease states in both cancers and neurodegenerative diseases, a large proportion of ALP and UPS genes affected only in later stages of disease compared to the early implication of these genes in early stages of cancers.