Proteostasis signatures in human diseases
Fig 5
Temporal progression of proteostasis perturbations across disease types.
Patient samples from each disease was compared against against healthy controls. Differential gene analysis reveals that perturbation of the proteostasis network (PN) occurred progressively in neurodegenerative diseases but early in cancers. Each point represents a gene significantly perturbed in disease compared to controls, coloured by its direction and magnitude of change in disease conditions.