Proteostasis signatures in human diseases
Fig 4
Proteostasis signatures of disease.
(A) Unsupervised clustering of cancers, neurodegenerative diseases, autoimmune diseases, and cardiovascular disease resulted in 4 clusters. The clusters were mostly by disease type, with the notable exception of pancreatic cancer and kidney cancer clustering with autoimmune diseases. (B) Proteostasis signature trends reveal that cancers and autoimmune diseases have a large proportion of common genes perturbed in similar patterns. In contrast, neurodegenerative diseases are perturbed in opposite directions. Each bar represents a gene from the relevant proteostasis network pathway. (C) Functional implications of the proteostasis signatures. The top enriched pathways (up to 10 each) for upregulated (red bars) and downregulated (blue bars) genes for each cluster type are shown.