Proteostasis signatures in human diseases
Fig 3
Characteristic proteostasis perturbation states and patterns in disease.
(A) Three generalised proteostasis perturbation states are capable of discriminating disease types: (i) ALP + UPS + ER- (cancers), (ii) ALP + UPS + ER+ (neurodegenerative diseases), and (iii) ALP + UPS- and ER+ (other disease types analysed in this study). (B) Distinct patterns in enriched proteostasis network pathways (red spider plots) and functional classes (blue spider plots) reflect disease-relevant trends – notably, cancers and neurodegenerative diseases have distinct enrichment patterns compared to cardiovascular, autoimmune, reproductive, respiratory, and endocrine that have fairly similar patterns. The spider plots depict trends of over-representation of the relevant proteostasis network pathways and functional classes across all 7 disease types. Over-representation was determined using the hypergeometric test (p-value < 0.01).