Electrodiffusion dynamics in the cardiomyocyte dyad at nano-scale resolution using the Poisson-Nernst-Planck (PNP) equations
Fig 17
RyR activation time for different values of the dyad width (Li) and the intracellular Ca2+ diffusion coefficient () in the PNP and reaction-diffusion models.
The RyR activation time is defined as time from the membrane Ca2+ channel is opened until the Ca2+ concentration outside of an apposing RyR channel reaches 0.5 M. The PNP results are also displayed in Fig 14. We have used
ns and an adaptive mesh like illustrated in Fig 3. Note that the electrical potential computed in the PNP model is used to compute the transmembrane fluxes in the reaction-diffusion model.